APIDRA PI PDF

PI & CMI Trade Names and Active Ingredients containing insulin glulisine. 1 Documents available. Need more information on a Apidra, CMIPI, Insulin glulisine. PI & CMI Trade Names and Active Ingredients containing insulin. 42 Documents Actrapid, PI, Insulin – human (human insulin) Apidra, CMIPI, Insulin glulisine. Apidra PI MKT. #v Page 1. PRODUCT INFORMATION. APIDRA APIDRA [insulin glulisine injection {rDNA origin}] is a recombinant human insulin .

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Cochrane Database Syst Rev. Some of the symptoms of an allergic reaction may include:.

Vials that are first carried as a spare for a while must also be discarded 28 days after being removed from the refrigerator. Published online Nov Lipodystrophy and weight gain Lipodystrophy and weight gain can each occur in adult subjects on long-term glulisine therapy.

Apidra mixed with NPH insulin should be injected immediately after mixing. All medicines have risks and benefits. A quality-of-life assessment of intensive insulin therapy using insulin lispro switched from short-acting insulin and measured by an ITR-QOL questionnaire: Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces.

The main outcome data in the efficacy studies were changes in HbA 1c at study completion. Pregnancy may make managing your diabetes more difficult.

It is very important that you manage your diabetes carefully. More severe symptoms of hypoglycaemia, including:. This is useful in young children, in whom it may be difficult to accurately predict carbohydrate intake. Diet and low calorie soft drinks do NOT contain sugar and are unsuitable to take for hypoglycaemia. They are usually mild and short-lived.

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However, a number of studies, mainly in adults, have shown higher satisfaction in subjects on lispro or aspart compared with RHI. In vitro studies do not suggest any increase in the risk of mitogenesis with glulisine.

Only mix Apidra with another insulin if your doctor has instructed you to do so. Based on these findings, Philotheou et al 25 concluded that glulisine is noninferior to lispro in the long-term reduction of HbA 1c in pediatric patients with type I diabetes. Empty disposable pens must never be reused and must be properly discarded.

Safety Studies suggest that glulisine has a similar safety profile to the other new rapid-acting insulin analogs and that it is well tolerated. Apidra should be used within 15 minutes before or immediately after a meal. The most common adverse event with glulisine, as with all insulins is hypoglycemia. The baseline characteristics of these adult type 1 diabetes participants were similar between the two groups glulisine vs lispro.

Use a different injection site each injection so the same site is not used more often than once a month. Level 8, 56 Cawley Street. Your doctor may tell you to use a long-acting insulin in combination with Apidra. Insulin and its analogs lower serum glucose levels by facilitating glucose uptake in skeletal muscle and fat, and by inhibiting gluconeogenesis, glycogenolysis, lipolysis, and proteolysis through its effect on the insulin receptor.

Philotheou et al spidra conducted a week multicenter open centrally randomized, parallel group, noninferiority trial of children and adolescents, aged 4 to 17 years with type 1 diabetes using glargine once daily in the evening or NPH twice daily as basal insulin and glulisine or lispro as the apira insulin.

Hypersensitivity and Insulin injection site reactions In children no generalized hypersensitivity reactions have been reported, although there are few studies in this population.

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There have been limited pl in children evaluating pharmacokinetics and pharmacodynamics of glulisine. Insuline glulisine imparts effective glycaemic control pk patients with type 2 diabetes. To help ensure an accurate dose each time, patients should follow the steps in the Instruction Leaflet accompanying the pen; otherwise they may not get the correct amount of insulin, which may affect their blood glucose.

A second in vitro study assessed the stability of glulisine and aspart during simulated use in insulin pumps flow rates 0.

Fast-Acting, Mealtime Insulin | Apidra® (insulin glulisine [rDNA origin] injection)

One study, utilizing reverse-phase high performance liquid chromatography to assess resistance to isoelectric precipitation of various types of insulin, 16 found that the resistance was highest for aspart and lowest for glulisine, but the clinical significance of this is unclear.

No specific studies have addressed quality of life QoL in patients on glulisine.

Remove the needle from the vial. Optimized basal-bolus insulin regimens in type 1 diabetes: National Center for Biotechnology InformationU. Ask your doctor if you have any questions about why Apidra has been prescribed for you.

Other than urticaria in a patient on RHI, details of the adverse reactions were not provided. With one hand, stabilise the skin by spreading it or pinching up a large area, as recommended by your healthcare professional. How to use Apidra Your doctor, pharmacist or diabetes educator will have shown you how to use Apidra.